Tounge, Brett A. : rechercher sur Z-Library

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1

Discovery of piperidine carboxamide TRPV1 antagonists

Wing S. Cheung, Raul R. Calvo, Brett A. Tounge, Sui-Po Zhang, Dennis R. Stone, Michael R. Brandt, Tasha Hutchinson, Christopher M. Flores, Mark R. Player

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 253 KB

english, 2008

2

Chemical Information Based Scaling of Molecular Descriptors: A Universal Chemical Scale for Library Design and Analysis.

Brett A. Tounge, Lori B. Pfahler, Charles H. Reynolds

Journal:

Année:

2002

Fichier:

PDF, 25 KB

2002

3

Defining Privileged Reagents Using Subsimilarity Comparison.

Brett A. Tounge, Charles H. Reynolds

Journal:

Année:

2004

Fichier:

PDF, 7 KB

2004

4

Recoupling of Heteronuclear Dipolar Interactions with Rotational-Echo Double-Resonance at High Magic-Angle Spinning Frequencies

Christopher P Jaroniec, Brett A Tounge, Chad M Rienstra, Judith Herzfeld, Robert G Griffin

Journal:

Journal of Magnetic Resonance

Année:

2000

Langue:

english

Fichier:

PDF, 120 KB

english, 2000

5

Synthesis and biological evaluation of type VI β-turn templated RGD peptidomimetics

Christopher J. Creighton, Yanming Du, Rosemary J. Santulli, Brett A. Tounge, Allen B. Reitz

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 154 KB

english, 2006

6

The role of molecular size in ligand efficiency

Charles H. Reynolds, Scott D. Bembenek, Brett A. Tounge

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 504 KB

english, 2007

7

Potent, nonpeptide inhibitors of human mast cell tryptase. Synthesis and biological evaluation of novel spirocyclic piperidine amide derivatives

Michael J. Costanzo, Stephen C. Yabut, Han-Cheng Zhang, Kimberley B. White, Lawrence de Garavilla, Yuanping Wang, Lisa K. Minor, Brett A. Tounge, Alexander N. Barnakov, Frank Lewandowski, Cynthia Mill

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 338 KB

english, 2008

8

An unusual intramolecular transfer of the fluorobenzyl cation between two remote amidic nitrogen atoms induced by collision in the gas phase

Zhengyin Yan, Brett Tounge, Gary W. Caldwell

Journal:

Rapid Communications in Mass Spectrometry

Année:

2012

Langue:

english

Fichier:

PDF, 1.35 MB

english, 2012

9

Piperidine-containing β-arylpropionic acids as potent antagonists of αvβ3/αvβ5 integrins

Bart L. De Corte, William A. Kinney, Li Liu, Shyamali Ghosh, Livia Brunner, William J. Hoekstra, Rosemary J. Santulli, Robert W. Tuman, Judith Baker, Candace Burns, Jef C. Proost, Brett A. Tounge, Bru

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 320 KB

english, 2004

10

A two-state homology model of the hERG K+ channel: application to ligand binding

Ramkumar Rajamani, Brett A. Tounge, Jian Li, Charles H. Reynolds

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 238 KB

english, 2005

11

Linear interaction energy models for β-secretase (BACE) inhibitors: Role of van der Waals, electrostatic, and continuum-solvation terms

Brett A. Tounge, Ramkumar Rajamani, Ellen W. Baxter, Allen B. Reitz, Charles H. Reynolds

Journal:

Journal of Molecular Graphics and Modelling

Année:

2006

Langue:

english

Fichier:

PDF, 595 KB

english, 2006

12

Calculation of the Binding Affinity of β-Secretase Inhibitors Using the Linear Interaction Energy Method

Tounge, Brett A., Reynolds, Charles H.

Journal:

Journal of Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 394 KB

english, 2003

13

Ligand efficiency and fragment-based drug discovery

Scott D. Bembenek, Brett A. Tounge, Charles H. Reynolds

Journal:

Drug Discovery Today

Année:

2009

Langue:

english

Fichier:

PDF, 669 KB

english, 2009

14

Ligand Binding Efficiency: Trends, Physical Basis, and Implications

Reynolds, Charles H., Tounge, Brett A., Bembenek, Scott D.

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2008

15

NMR probes of vectoriality in the proton-motive photocycle of bacteriorhodopsin: evidence for an ‘electrostatic steering’ mechanism

Judith Herzfeld, Brett Tounge

Journal:

Biochimica et Biophysica Acta (BBA) - Bioenergetics

Année:

2000

Langue:

english

Fichier:

PDF, 274 KB

english, 2000

16

2-Amino-3,4-dihydroquinazolines as Inhibitors of BACE-1 (β-Site APP Cleaving Enzyme): Use of Structure Based Design to Convert a Micromolar Hit into a Nanomolar Lead

Baxter, Ellen W., Conway, Kelly A., Kennis, Ludo, Bischoff, François, Mercken, Marc H., De Winter, Hans L., Reynolds, Charles H., Tounge, Brett A., Luo, Chi, Scott, Malcolm K., Huang, Yifang, Braeken,

Journal:

Journal of Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 155 KB

english, 2007

17

Collagen-Related Peptides: Self-Assembly of Short, Single Strands into a Functional Biomaterial of Micrometer Scale

Cejas, Mabel A., Kinney, William A., Chen, Cailin, Leo, Gregory C., Tounge, Brett A., Vinter, Jeremy G., Joshi, Pratik P., Maryanoff, Bruce E.

Journal:

Journal of the American Chemical Society

Année:

2007

Langue:

english

Fichier:

PDF, 105 KB

english, 2007

18

[Methods in Enzymology] Fragment-Based Drug Design - Tools, Practical Approaches, and Examples Volume 493 || Designing a Diverse High-Quality Library for Crystallography-Based FBDD Screening

Tounge, Brett A.

Année:

2011

Langue:

english

Fichier:

PDF, 563 KB

english, 2011

19

Frequency Selective Heteronuclear Dipolar Recoupling in Rotating Solids: Accurate 13 C− 15 N Distance Measurements in Uniformly 13 C, 15 N-labeled Peptides

Jaroniec, Christopher P., Tounge, Brett A., Herzfeld, Judith, Griffin, Robert G.

Journal:

Journal of the American Chemical Society

Année:

2001

Langue:

english

Fichier:

PDF, 234 KB

english, 2001

20

Noncovalent Self-Assembly of Bicyclo[4.2.2]diketopiperazines: Influence of Saturation in the Bridging Carbacyclic Ring

Du, Yanming, Creighton, Christopher J., Tounge, Brett A., Reitz, Allen B.

Journal:

Organic Letters

Année:

2004

Langue:

english

Fichier:

PDF, 201 KB

english, 2004

21

Electron Density Guided Fragment-Based Lead Discovery of Ketohexokinase Inhibitors

Gibbs, Alan C., Abad, Marta C., Zhang, Xuqing, Tounge, Brett A., Lewandowski, Francis A., Struble, Geoffrey T., Sun, Weimei, Sui, Zhihua, Kuo, Lawrence C.

Journal:

Journal of Medicinal Chemistry

Année:

2010

Langue:

english

Fichier:

PDF, 3.56 MB

english, 2010

22

Measurement of Dipolar Couplings in a Uniformly 13 C, 15 N-Labeled Membrane Protein: Distances between the Schiff Base and Aspartic Acids in the Active Site of Bacteriorhodopsin

Jaroniec, Christopher P., Lansing, Jonathan C., Tounge, Brett A., Belenky, Marina, Herzfeld, Judith, Griffin, Robert G.

Journal:

Journal of the American Chemical Society

Année:

2001

Langue:

english

Fichier:

PDF, 48 KB

english, 2001

23

The 2 1Ag state of trans,trans-1,3,5,7-octatetraene in free jet expansions

Petek, Hrvoje, Bell, Andrew J., Choi, Young S., Yoshihara, Keitaro, Tounge, Brett A., Christensen, Ronald L.

Journal:

The Journal of Chemical Physics

Année:

1993

Langue:

english

Fichier:

PDF, 1.57 MB

english, 1993

24

One- and two-photon fluorescence excitation spectra of the 2 1Ag states of linear tetraenes in free jet expansions

Petek, Hrvoje, Bell, Andrew J., Choi, Young S., Yoshihara, Keitaro, Tounge, Brett A., Christensen, Ronald L.

Journal:

The Journal of Chemical Physics

Année:

1995

Langue:

english

Fichier:

PDF, 583 KB

english, 1995

25

Hit Triage Using Efficiency Indices after Screening of Compound Libraries in Drug Discovery

Reitz, Allen, Smith, Garry, Tounge, Brett, Reynolds, Charles

Journal:

Current Topics in Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 267 KB

english, 2009

26

Inhibitor Bound Dengue NS2B-NS3pro Reveals Multiple Dynamic Binding Modes

Gibbs, Alan C, Steele, Ruth, Liu, Gaohua, Tounge, Brett A., Montelione, Gaetano

Journal:

Année:

2018

Langue:

english

Fichier:

PDF, 2.89 MB

english, 2018

27

Structure-Function Study of Quinazolinone-Based Vitronectin Receptor (αVβ3) Antagonists: Computer-Assisted Analysis of Ligand-Receptor Interactions

Lawson, Edward, Kinney, William, Costanzo, Michael, Hoekstra, William, Kauffman, Jack, Luci, Diane, Santulli, Rosemary, Tounge, Brett, Yabut, Stephen, Andrade-Gordon, Patricia

Journal:

Letters in Drug Design & Discovery

Année:

2004

Langue:

english

Fichier:

PDF, 137 KB

english, 2004